Download An Illustrated Pocketbook of Parkinson’s Disease and Related by G. David Perkin PDF

By G. David Perkin

An authoritative creation to Parkinson's disorder and its comparable issues and syndromes, this ebook presents a concise evaluate of the illness and its analysis and administration. the writer offers samples of scientific, investigative (CT, MRI, and puppy) and pathological photos with succinct descriptive textual content of the issues featured. He describes the stipulations regarding Parkinson's ailment, and the images supply pathological macroscopic and microscopic sections, numerous imaging experiences, and info of circulation problems more often than not. The booklet will function an invaluable instructing device that demonstrates the imaging and pathology of the illness.

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Bradykinesia is present to a varying degree, with some patients presenting as a pure akinetic syndrome. Tremor occurs in around 12–16% of cases. A subcortical, rather than cortical, dementia is characteristic, but, in the later stages, a dementia of frontal type with memory impairment, dysphasia and apraxia is common, In most cases, dopa therapy is ineffective in PSP and almost never influences the ophthalmoplegia. Imaging changes in PSP include both generalized and selective brain stem atrophy (Figure 29).

Dementia is not a feature of multiple system atrophy, nor is there an ophthalmoplegia (although this is recorded in both sporadic and familial forms of OPCA). Although poor or absent dopa responsiveness is the norm, some cases— confirmed at postmortem examination—may show a response comparable to that seen in idiopathic Parkinson’s disease. Multiple system atrophy usually presents in the sixth decade of life. The median survival is of the order of 7–8 years. Men are slightly more often affected than women.

The underlying hepatic disease may be silent. The condition is likely to coexist with episodes of acute hepatic encephalopathy, but its severity does not correlate with the frequency of such episodes. Indeed, in some cases, episodes of hepatic encephalopathy have not been 48 AN ILLUSTRATED POCKETBOOK OF PARKINSON’S DISEASE Figure 50 Torsion dystonia: scoliosis reported. The initial presentation may be with either the hepatic or neurological features. As regards the movement disorder, dystonia is uncommon, whereas chorea and postural and action tremors are often prominent.

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